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Understanding Itchy Palms Without a Rash: A Clinical Perspective for 2026

"When your palms itch without visible skin inflammation, redness, or bumps, it suggests an internal physiological cause rather than a topical contact dermatitis. This phenomenon, clinically referred to as pruritus of the palms, often points toward systemic triggers, neurological conditions, or metabolic imbalances that require diagnostic differentiation. Differential Diagnosis for Non-Dermatological Palmar Pruritus In medical diagnostics, when a patient presents with itchy skin absent of primary lesions—such as hives, vesicles, or scales—the focus shifts from the epidermis to the systemic environment. By 2026, clinical protocols prioritize the..."

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