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Stiff Person Syndrome (SPS): The 2026 Diagnostic Shift and the Push for Targeted Immunotherapy

"Breakthroughs in biomarker identification and a surge in clinical trial participation are redefining the prognosis for patients diagnosed with Stiff Person Syndrome (SPS) as of September 2026. While the ultra-rare neurological disorder remains a complex challenge for clinicians, new longitudinal data suggests that early, aggressive intervention—coupled with a more nuanced understanding of the GAD65 antibody landscape—is successfully altering the disease trajectory for thousands of patients globally. Key Metric Status (September 2026) Primary Driver Enhanced GAD65 antibody screening protocols Emerging Therapy B-cell depletion therapy (CD20-tar..."

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